IV Tildren for Navicular Syndrome The efficacy of administering the injectable bisphosphonate medication for horses (Tildren) in two different ways was evaluated for the treatment of navicular syndrome. Twelve horses diagnosed with bilateral navicular syndrome were randomly assigned to receive Tildren either systemically by intravenous injection or by using regional limb perfusion, where the drug is “back-flushed” directly into the blood vessels of the lower limb so that it is delivered to the lower limb and hoof in a more direct, concentrated manner.

Researchers in Canada used cadaver limbs to study the effects of hoof angles and loading patterns on joint surface contact areas in the fetlock. Eight limbs from Standardbred horses that died for reasons unrelated to this study were fitted into a mechanical pendulum device to simulate hoof strike at a trot. Strips of pressure-sensitive film were placed across the joint surfaces inside the fetlock to measure contact areas, and the limb was loaded while simulating flat, toe-first and heel-first landings.